Polynucleotides

What Are Polynucleotides?

Polynucleotides are a regenerative injectable treatment made from highly purified DNA fragments, most commonly derived from salmon DNA. Rather than adding volume to the skin, they work by stimulating your own skin’s natural repair and renewal processes at a cellular level — encouraging healthier, stronger, more resilient tissue from the inside out.

This makes polynucleotides quite different from dermal fillers, which are designed to add structure and volume, and even from standard skin boosters, which primarily focus on hydration. Polynucleotides are more deeply regenerative and healing-focused, which is why they are increasingly used to repair sun damage, calm tired or compromised skin, and restore quality to areas that have lost their natural bounce.

At Skin Rejuvenation Clinic, polynucleotides are prized for their ability to improve overall skin quality — boosting elasticity, refining texture, and supporting the skin’s long-term health and resilience. They are especially popular for repairing visible skin damage, rejuvenating the delicate under-eye area, and giving tired-looking skin a genuine, lasting lift in condition.

If you are looking for a treatment that works with your body’s own repair mechanisms rather than simply masking concerns, polynucleotides offer a gentle, science-backed route to healthier-looking skin.

How Does It Work?

During your treatment, the polynucleotide solution is delivered using a series of fine, shallow injections placed carefully across the treatment area. Because the technique is so precise, your practitioner can target exactly the areas that need the most support, whether that is fine lines, areas of damage, or skin that has simply lost some of its former vitality.

Once injected, the polynucleotides are recognised by your body as a natural building block. This triggers a cascade of regenerative activity — fibroblasts in the deeper layers of your skin are encouraged to produce fresh collagen and elastin, while the surrounding tissue benefits from improved hydration and repair signalling.

Over the following weeks, you should notice your skin becoming firmer, better hydrated, and visibly healthier as this rebuilding process continues beneath the surface. The effect is gradual and cumulative, reflecting the way the treatment works in harmony with your own biology rather than creating an instant, artificial change.

What Can I Expect?

Your polynucleotide appointment typically takes around 30 minutes from start to finish, making it an easy treatment to fit into a busy day. If you are concerned about sensitivity, a numbing cream can be applied beforehand to keep you comfortable throughout.

The treatment itself involves a series of fine needle injections into the target area. Most people find the discomfort minimal, often describing it as a series of light pinpricks rather than anything painful.

One of the major advantages of polynucleotides is the minimal downtime involved. You can generally return to your normal routine straight away. It is common to notice some mild swelling or small, temporary bumps at the injection sites immediately afterwards — this is a completely normal part of the process and usually settles within a day or two.

Results & How Long Do They Last?

Polynucleotides are designed to be used as a course rather than a single, one-off treatment. We typically recommend a course of 3 to 4 sessions, spaced around 2 to 4 weeks apart, to allow your skin’s regenerative processes to build progressively and deliver the full benefit of the treatment.

Rather than an instant transformation, you should expect your skin quality to improve gradually session by session, as collagen and elastin production builds and hydration levels rise. Many clients notice their skin looking calmer, firmer and more even in tone as the course progresses.

Once your initial course is complete, the improvements in skin quality tend to be long-lasting, though skin is a living, changing tissue and benefits naturally soften over time. Maintenance sessions every few months are a popular way to sustain and build on your results, keeping your skin looking consistently healthy and refreshed.

Am I a Good Candidate?

Polynucleotides are particularly well suited to anyone dealing with compromised, damaged, ageing or thin skin that could benefit from genuine cellular repair rather than added volume. If your skin feels tired, depleted or lacking in resilience, this regenerative approach can make a meaningful difference.

They are also an excellent choice for under-eye concerns, where skin is especially delicate and prone to showing signs of fatigue, as well as for those dealing with post-acne scarring or textural irregularities that respond well to a healing-focused treatment.

If you are looking for restoration and repair rather than volumising, polynucleotides may be exactly what your skin needs. They also combine beautifully with other treatments as part of a broader, considered skin-health plan — your practitioner can advise on the best combination for your individual goals during your consultation.

Aftercare

Caring for your skin properly in the days following treatment helps support the regenerative process and ensures you get the very best results. Please follow this simple guidance:

• Avoid touching, rubbing or applying pressure to the injection points for at least 24 hours after treatment.
• Avoid strenuous exercise, alcohol and excessive heat (including saunas, steam rooms and hot baths) for 24 hours to reduce the risk of swelling or irritation.
• Mild swelling or small bumps at the injection sites are a normal part of the healing response and will usually settle within a day or two — there is no need for concern.
• Stay well hydrated in the days following your appointment, as good hydration supports your skin’s natural repair process and helps maximise your results.

Why Skin Rejuvenation Clinic?

At Skin Rejuvenation Clinic, every polynucleotide treatment is carried out by genuinely experienced practitioners who understand the science behind regenerative skincare and take the time to tailor each course to your individual skin needs. We only ever use authentic, premium-grade product, so you can feel completely confident in both the safety and the quality of your treatment.

We welcome you at either of our two clinic locations — Cippenham, Slough, or Harley Street, London — wherever is most convenient for you. If you would like to find out whether polynucleotides are right for your skin, we invite you to book a free consultation with our team and discuss your goals in a relaxed, no-pressure setting.